Exploration and Targeting the Epigenome of Fusion Positive Rhabdomyosarcoma

Javed Khan, MD
Deputy Chief Genetics Branch and Senior Investigator
Oncogenomics Section
Center for Cancer Research CCR

Tuesday, September 29, 2020
11:00 am – 12:00 pm
Webinar

• Rhabdomyosarcoma (RMS) genomics
• Reprograming of the epigenome by PAX3-FOXO1
• Hijacking of the FOXO1 enhancer by PAX3-FOXO1 translocation
• Defining the core regulatory circuitry of fusion positive RMS
• Drugging the undruggable: inhibitors of PAX3-FOXO1 activity
  • BRD4i
  • HDACi

seminar flyer and contact information