Agenor Limon from University of Texas to Present in Translational Genomics Virtual Distinguished Lecture Series

 

 

Electrophysiology of Human Native Receptors and its Integration in Multiomic Data in Health and Disease

Agenor Limon, PhD
Mitchell Center for Neurodegenerative Diseases
Department of Neurology
University of Texas Medical Branch (UTMB)

Tuesday, November 9, 2021
11:00 am – 12:00 pm

Webinar Registration

Alterations in synaptic function have been found in transcriptomic, genetic, and proteomic studies of neurological and mental disorders. Clinical and preclinical studies suggest that synaptic dysfunction and behavioral abnormalities in disorders like Alzheimer’s disease and schizophrenia may be mechanistically linked to the emergence of imbalances between excitatory (E) and inhibitory (I) receptors. However, until recently, the electrophysiological E/I synaptic ratio had only been measured in animal models. Using pioneering methods developed in the lab, that include the reactivation and microtransplantation of synaptic receptors from frozen human brains, we have obtained electrophysiological metrics of global synaptic E/I ratios in cortical brain regions of subjects that were affected by Alzheimer’s Disease and synaptic measurements in schizophrenia. By integrating these functional metrics with large datasets across different levels of complexity (anatomical, transcriptomic, proteomic) we found that the global synaptic E/I ratio in the cortex of subjects without a psychiatric or neuro- logical diagnosis is remarkable stable in humans across postmortem intervals and brain banks; however, in addition to the synaptic loss found in AD, there are severe E/I imbalances in cortical regions associated to the behavioral abnormalities commonly found in these disorders. These analyses provide a window on the physiology of neurotransmitter receptors that were working in the human brain, and an opportunity to use this knowledge in the development of effective therapeutic strategies.

  seminar flyer and contact information
  registration

Department Chair John Carpten to Chair President Biden’s National Cancer Advisory Board

President Joe Biden has appointed Dr. Carpten to serve as chair of the administration’s National Cancer Advisory Board, which plays an important role in guiding the director of the National Cancer Institute in setting the course for the national cancer research program. 

 

White House Press Release


USC News

Translational Genomics Concluded Genomic Diversity and Human Disease Lecture Series

We wish to thank all our speakers for bringing their expertise and engaging in candid discussions with students throughout the semester.  Please see full list of lectures here. 

Department Chair Dr. Carpten Kicked Off Translational Genomics Virtual Distinguished Lecture Series

   

USC Translational Genomics:
Accelerating Improvements in Healthcare at USC KSOM through Intentional Integration between Basic Discovery Research and Clinical Science

John D. Carpten, PhD
Professor, USC Department of Urology
Chair, USC Department of Translational Genomics
Director, USC Institute for Translational Genomics
Director, USC Molecular Genomics Core
Co-Leader, Norris Comprehensive Cancer Center

Tuesday, August 18, 2020
11:00 am – 12:00 pm
Webinar

In 2016, the USC Department of Translational Genomics was created under the leadership of the founding chair John Carpten, PhD with co-leadership by Vice Chair Dr. David Craig.  The mission of USC Translational Genomics is to help the Keck School of Medicine realize its full potential in improving patient outcomes through the intentional integration of basic and clinical research.  The foundational components of our department include genome science and biomedical informatics.  The department currently includes eight faculty members dedicated to scholarship, teaching and education, and service to the community.  The department hosts several major grants and is focused on translating genomic discoveries into new knowledge that may someday have clinical application.  The department also contributes to the educational mission of the university through its master’s degree programs in Translational Biotechnology and Translational Biomedical Informatics.   Diversity is also a major component of our departmental foundation, including being among the world leaders in research studies that aim to understand the relationship between population differences and disease incidence and outcomes, and in our intentional goals for biomedical workforce diversity.

  seminar flyer and contact information
  presentation slides:      Deck 1           Deck 2